
I hear you owe that boy a SIGNIFICANT debt.
Game of Thrones Season 3, Episode 3

Significant improvement
over the old neighbor.
The Big Bang Theory Season 1, Episode 1

This is a natural human process
and we're talking about SIGNIFICANT savings.
The Big Bang Theory Season 1, Episode 4

with his SIGNIFICANT other.
The Big Bang Theory Season 7, Episode 5

Well, you've lived with
your SIGNIFICANT other for some time.
The Big Bang Theory Season 10, Episode 4